Correlation between MMP and TIMP levels and elastic moduli of ascending thoracic aortic aneurysms
Highlights
- • The relationship between the elastic modulii and the MMPs/TIMPs levels are found in aortic wall specimens.
- • Elastic moduli is obtained non-invasively and the values of MMPs and TIMPs levels are obtained from the non-invasive determination of the elasticity of the aortic wall.
- • The method proposed here can improve the prediction of outcomes of ascending aortic aneurysms.
Abstract
Objective
The objective of this preliminary investigation is to determine if there is a relation between the biological levels of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinase (TIMP) and the elastic moduli of the ascending aortic wallin patients with ascending thoracic aortic aneurysms (ATAA). Methods: Circumferential specimens from twelve patients with ATAA were obtained from the greater curvature and their tensile properties (maximum elastic modulus) were tested uniaxially. The levels of MMP1, 2, 3, 8, and 9 as well as TIMP1 and 2 were determined in these aortic wall specimens using MMP/TIMP antibodies array.