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Recurrent Rejection Raises Graft Rejection Risk in Pediatric Heart Transplant: PHTS Analysis

Nov 20, 2024 by
Natalie Morrison, CRTonline.org

Children who experience recurrent mixed or antibody-mediated rejection episodes of heart transplants face a higher risk of losing their graft, according to a new multi-institutional analysis.

Both Social and Genetic Factors Can Boost CHD Risk Prediction Accuracy: New AoU Analysis

Nov 19, 2024 by
Natalie Morrison, CRTonline.org

Both genetic and social factors should play a joint role in boosting the accuracy of risk modeling for coronary heart disease (CHD), said the authors of a new analysis of the ‘All of Us’ (AoU) program, stressing that racial identity is a crucial driver behind bigger social burden.

Halting HF Treatment Poses Risk of Rapid Health Decline, Review Warns

Nov 19, 2024 by
Will Chu, CRTonline.org

A recent review reveals the significant risks heart failure patients face if they discontinue long-term drug treatments, which can include a rapid return to baseline and worsening rebound.

Researchers Highlight Statistical Hurdles Hindering Mortality Reductions in HFmrEF and HFpEF Patients

Nov 19, 2024 by
Will Chu, CRTonline.org

A new article offers insight on the challenges of reducing mortality rates in patients with heart failure with mildly reduced ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF).

Good Concordance Between Echo and CMR Reference, Study Reports

Nov 13, 2024 by
Nathan Gray, CRTonline.org

The quantitation of aortic regurgitation (AR) severity by transthoracic echocardiogram has good concordance against a cardiac magnetic resonance reference standard, according to a new analysis that also proposes simplified echo algorithms to evaluate significant and mild AR.

Time to Change the Guidelines? Early Echocardiographic Markers of Left Ventricular Dysfunction May Offer Survival Benefit

Nov 13, 2024 by
Nathan Gray, CRTonline.org

Patients with asymptomatic clinically significant chronic aortic regurgitation incur a survival penalty when Class I/IIa guideline recommendations are attained compared with patients who do not yet reach guideline status but do show early echocardiographic markers of early left ventricular dysfunction, new data suggests.

Rural Communities in the U.S. Have Higher Cardiovascular Mortality Rates: CDC Data

Nov 13, 2024 by
Bailey G. Salimes, CRTonline.org

In the post-pandemic U.S., cardiovascular death rates are 1.5 times higher in rural areas compared with urban areas, a brief report shows, and socioeconomic factors are the most significant cause for these outcomes.

Study Identifies BAG3 Gene Variant’s “Bidirectional” Role for DCM and HCM Risk

Nov 13, 2024 by
Will Chu, CRTonline.org

In newly published research, researchers identify a genetic variant in the BAG3 gene that they think plays a complex, dual role in the risk spectrum of dilated cardiomyopathy and hypertrophic cardiomyopathy.

‘Optimal’ TR Reduction Associated With Better Functional, Clinical Outcomes After T-TEER: Registry Data

Nov 06, 2024 by
Nathan Gray, CRTonline.org

An ‘optimal’ procedural result of grade of 0/1+ regurgitation after tricuspid edge-to-edge repair (T-TEER) is associated with improved outcomes and functional status, according to an analysis of real-world patient data from the Spanish TRI-SPA registry.

Coronary Sinus Reducer Improves QoL, Symptom Severity in Patients with Refractory Angina: REDUCER-I Trial

Nov 06, 2024 by
Will Chu, CRTonline.org

A new study outlines the substantial improvements in quality of life, symptom severity and exercise capacity among patients implanted with the Coronary Sinus (CS) Reducer in treating patients with refractory angina.

CS Reducer Improves Angina Symptoms, QoL in CMD Patients: NeoVasc/Shockwave Medical-Supported Trial

Nov 06, 2024 by
Will Chu, CRTonline.org

Newly published findings reveal that the coronary sinus (CS) reducer significantly reduces angina symptoms and improves quality of life for patients with coronary microvascular dysfunction (CMD).

TEER Has Similar Efficacy, Better Safety Post-Mitral Valve Surgery in Atrial and Ventricular Functional MR: MATTERHORN Trial

Oct 30, 2024 by
Abhishek Chaturvedi, MD, CRTonline.org

In patients with atrial functional mitral regurgitation, transcatheter edge-to-edge repair has similar efficacy and better safety profile than mitral valve surgery, according to a post-hoc analysis from the MATTERHORN trial.

M-TEER Safe, Effective Option for Degenerative MR Patients: CLASP IID Trial

Oct 30, 2024 by
Dan Haberman, MD, CRTonline.org

Two-year results from the CLASP IID Randomized Trial and Registry confirm the sustained safety and effectiveness of the PASCAL system in treating a broad population of degenerative mitral regurgitation (DMR) patients.

Culture Clearance Observed in Patients With Right-Sided Infective Endocarditis Post-PMA: CLEAR-IE Registry

Oct 30, 2024 by
Bailey G. Salimes, CRTonline.org

Patients with right-sided infective endocarditis experience culture clearance after percutaneous mechanical aspiration (PMA), according to results from the CLEAR-IE trial.

3-Month vs. 12-Month DAPT: TARGET DAPT Study Finds Comparable Outcomes for PCI Patients With Firehawk Stent

Oct 30, 2024 by
Lior Lupu, MD, MBA, CRTonline.org

Short-term DAPT for patients undergoing percutaneous coronary intervention with the biodegradable-polymer rapamycin-eluting Firehawk stent is noninferior to extended-duration DAPT.

Novel Biodegradable Stent in TARGET IV Trial Shows TLF Outcomes Similar to Second-Generation Drug-Eluting Stents

Oct 30, 2024 by
Bailey G. Salimes, CRTonline.org

Considering target lesion failure outcomes at 1-year follow-up during the TARGET-IV study, the Firehawk biodegradable polymer sirolimus-eluting stent is noninferior to the currently used second-generation drug-eluting stents.

Artificial Intelligence-Based Quantitative Coronary Angiography is Non-Inferior to OCT-Guided PCI, FLASH Trial Suggests

Oct 30, 2024 by
Abhishek Chaturvedi, MD, CRTonline.org

In patients undergoing percutaneous coronary interventions (PCI) for significant coronary artery disease (CAD), AI-based quantitative coronary angiography (AI-QCA) is non-inferior to optical coherence tomography (OCT) guided PCI, according to results from the FLASH trial.

QFR Fails to Meet Non-Inferiority to FFR for Guiding Revascularization Decisions in Patients With Coronary Stenosis: FAVOR III

Oct 30, 2024 by
Waiel Abusnina, MD, CRTonline.org

According to the FAVOR III Europe trial, the Quantitative Flow Ratio (QFR)-guided revascularization strategy does not meet the non-inferiority criteria compared to the standard Fractional Flow Reserve (FFR)-guided strategy for intermediate coronary stenosis requiring functional assessment in terms of composite endpoint of death, myocardial infarction and unplanned revascularization.

Under-Expansion in ACURATE Neo2 Valve Carries Higher Risk of Death, Stroke: ACURATE IDE Trial

Oct 30, 2024 by
Bailey G. Salimes, CRTonline.org

Under-expansion is a potential factor in clinical outcomes for patients with severe, symptomatic aortic stenosis receiving the ACURATE neo2 valve, results from the head-to-head ACURATE IDE trial show.

EVOQUE TTVR Boosts Severe TR Quality of Life, Despite No 1-Year Mortality or Heart Failure Improvements: TRISCEND Trial

Oct 30, 2024 by
Natalie Morrison, CRTonline.org

Transcatheter tricuspid valve replacement (TTVR) with the EVOQUE system led to substantial quality of life improvements for severe tricuspid regurgitation (TR) patients versus optimal medical therapy (OMT) alone, according to a new 1-year analysis of the TRISCEND II pivotal trial.

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