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SGLT2i Potentially ‘Disease Modifying’ in Aortic Stenosis, Observational Study Concludes

Feb 21, 2025 by
Natalie Morrison, CRTonline.org

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) may slow the progression of non-severe aortic stenosis (AS), according to a new retrospective observational study in more than 11,500 patients.

Groundbreaking Study Uncovers CAD Patterns Characterizing FFR/iFR Measurement Discordance

Feb 21, 2025 by
Will Chu, CRTonline.org

A new study provides fresh insights on the physiological patterns influencing discordance between fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) in coronary artery disease (CAD).

SIBLINT-ISR Trial Shows Noninferiority of Sirolimus- vs Paclitaxel-Coated Balloon for In-Stent Restenosis

Feb 19, 2025 by
Bailey G. Salimes, CRTonline.org

A new sirolimus-coated balloon (SCB) is noninferior to a paclitaxel-coated balloon (PCB) in patients with in-stent restenosis (ISR) at 9-month follow-up and similar 1-year clinical events, a new study shows.

Novel Self-Centering Crossing Catheter Successful, Safe During TAVR for Severe AS

Feb 19, 2025 by
Bailey G. Salimes, CRTonline.org

A novel Self-Centering Guide Catheter (SCGC) used during transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis (AS) shows no safety concerns and successfully operates during TAVR, a first-in-human study shows.

FDA Device Approval: Are the Standards Sufficient or Do We Need Updates?

Feb 19, 2025 by
Bailey G. Salimes, CRTonline.org

The U.S. Food and Drug Administration (FDA) balances patient safety, clinician decision-making and regulatory flexibility in their approval process for medical devices but also must safely and efficiently continue to bring new technologies and innovations to patients, two recent viewpoint articles point out.

Optimizing Coronary Stent Expansion: Review Suggests New Algorithm for PCI Success

Feb 10, 2025 by
Nathan Gray, CRTonline.org

Coronary stent underexpansion (SU) remains a major challenge in percutaneous coronary intervention (PCI), increasing restenosis and thrombosis risks, according to a new review that proposes an intravascular imaging (IVI)-guided algorithm to systematically optimize stent expansion and improve patient outcomes.

Transapical TMVR: A Promising Alternative for Failed M-TEER Procedures

Feb 10, 2025 by
Will Chu, CRTonline.org

Study findings published in Feb 10 edition of JACC: Cardiovascular Interventions detail the effectiveness of transapical transcatheter mitral valve replacement (TMVR) following failed transcatheter edge-to-edge repair (M-TEER).

PERFORMANCE II Trial Notes Low Stroke Risk Demonstrated by Neuroguard IEP 3-in-1 Carotid Stent

Feb 10, 2025 by
Will Chu, CRTonline.org

Conclusions drawn from a recent study have pointed to the potential of a novel carotid stent system that could benefit patients at high risk of complications from carotid endarterectomy (CEA).

TR Stage May Influence 1-Year T-TEER Survival Outcomes: Registry Analysis

Feb 10, 2025 by
Nathan Gray, CRTonline.org

Tricuspid regurgitation (TR) disease stage may influence survival outcomes following tricuspid transcatheter edge-to-edge repair (T-TEER), according to a new analysis of 1-year follow-up data that suggests individuals with intermediate TR may receive the most substantial treatment benefits.

Fewer Recurrent Strokes, Deaths With Salt Substitutes vs Regular Salt: SSaSS Study

Feb 05, 2025 by
Bailey G. Salimes, CRTonline.org

In patients with a history of stroke, salt substitution is safe, and the risks of death and recurring stroke are reduced, a new cluster trial shows.

Poor Social Determinants of Health Linked to Poorer CV Health in Sexual Minorities: National Health Interview Survey Study

Feb 04, 2025 by
Bailey G. Salimes, CRTonline.org

Among individuals in sexual minority (SM) groups in the US, those with unfavorable social determinants of health (SDOH) profiles have worse cardiovascular health (CVH) scores and are at higher risk for cardiovascular mortality compared with heterosexual individuals, a new study shows.

Lower All-Cause Mortality in Mechanical vs Bioprosthetic Aortic Valve Replacement: Real-World Analysis

Feb 04, 2025 by
Bailey G. Salimes, CRTonline.org

Mechanical surgical aortic valve replacement (AVR) is independently associated with significant survival benefits compared with bioprosthetic AVR in patients aged 60 years and younger, a real-world analysis shows.

The Importance of Equity in the Development of Health Care AI Models: Viewpoint

Feb 04, 2025 by
Bailey G. Salimes, CRTonline.org

A viewpoint paper explains that equitable performance is the responsibility of health care-providing institutions when integrating artificial intelligence (AI) in clinical practice, as well as continuously developing AI applications to address long-standing inequities.

Out-of-Pocket Costs Burden HF Management, Cause Financial Strain: State-of-the-Art Review

Jan 30, 2025 by
Bailey G. Salimes, CRTonline.org

High out-of-pocket costs for heart failure management continue to create confusion, financial burdens, financial strain and financial toxicity for patients with chronic diseases in the U.S., leading to poor medication adherence and negative health outcomes, authors share in a state-of-the-art review.

Similar Outcomes Reported from Clinical Events Committee vs Investigator Adjudication Reports in Heart Failure Study: EMPEROR-Preserved Analysis

Jan 30, 2025 by
Bailey G. Salimes, CRTonline.org

In patients with heart failure with preserved ejection fraction (HFpEF), investigator adjudication reports similar accuracy and faster event accumulation compared with the clinical events committee (CEC) when assessing the impact of the Standardized Data Collection for Cardiovascular Trials (SCTI) criteria, an analysis of the EMPEROR-Preserved trial shows.

Artificial Intelligence Shows Potential in Enhancing Clinical Trials: Viewpoint

Jan 30, 2025 by
Bailey G. Salimes, CRTonline.org

The future of clinical trials will be revolutionized by artificial intelligence (AI), but AI advancements will need the help of coordinated care efforts, modernized digital infrastructure, new business models and streamlined regulatory processes to create a patient-centered approach in clinical research, a new viewpoint reports.

IVUS for FPA With DCB Shows Promising Clinical Outcomes in Patients With Complex FPA Lesions: IVUS-DCB Subgroup Analysis

Jan 22, 2025 by
Bailey G. Salimes, CRTonline.org

Guidance with intravascular ultrasound for the endovascular treatment of femoropopliteal artery disease using a drug-coated balloon is significantly associated with improved 12-month clinical outcomes, especially in patients who have complex FPA lesions, a subgroup analysis of the IVUS-DCB trial shows.

Impact of Environmental Events on Cardiovascular Health: Brief Report

Jan 22, 2025 by
Bailey G. Salimes, CRTonline.org

Extreme environmental events have a significant impact on cardiovascular health. As climate change continues to have an effect on the world, the need for evidence-based interventions and responses will continue to grow, a brief report explains.

Hypertension While Lying Down Carries Greater CVD Risks vs Hypertension While Seated: Cohort Study

Jan 22, 2025 by
Bailey G. Salimes, CRTonline.org

Hypertension while lying supine puts patients at higher risk for cardiovascular disease events compared with seated hypertension alone, a new cohort study shows.

Despite Recent Advances in LAAO, Questions Remain Over Patient, Device Selection: State-of-the-Art Review

Jan 14, 2025 by
Nathan Gray, CRTonline.org

While multiple advancements in left atrial appendage occlusion (LAAO) devices have emerged for stroke prevention and arrhythmia therapy, several unanswered questions remain, specifically regarding the patient and device selection and the management of complications, according to a new review.

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