DNA Damage and Repair in Patients With Coronary Artery Disease: Correlation With Plaque Morphology Using Optical Coherence Tomography (DECODE Study)
Highlights
- • DNA ligase activity is reduced in patients with stable angina.
- • Peripheral blood mononuclear cells exhibit differences in the expression of genes involved in the DNA damage response pathway (DDR) in patients with stable angina and non-ST-elevation myocardial infarction.
- • Genes implicated in the DDR correlate with atherosclerotic coronary plaque morphology
Abstract
Objective
The aim of this study was to examine DNA ligase activity and expression of DNA damage response pathway (DDR) genes in patients with stable angina (SA) and non-ST elevation myocardial infarction (NSTEMI) and determine whether they correlate with plaque morphology.