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  • Effect of Intravascular Cooling on Microvascular Obstruction (MVO) in Conscious Patients with ST-Elevation Myocardial Infarction Undergoing Primary PCI: Results from the COOL AMI EU Pilot Study

    • Posted: 10/03/2019
    • Author:

      Thomas R. Keeble, Grigoris V. Karamasis, Marco Noc, Beata Sredniawa, Daniel Aradi, Aleksandar N. Neskovic, Håkan Arheden, David Erlinge and Michael Holzer

    • 2019CRM

    Highlights

    • Rapid intra-vascular therapeutic hypothermia (TH) is safe and feasible to deliver in conscious STEMI patients.
    • In COOL AMI Pilot study the presence of MVO was high and similar in both study arms.
    • Patients with extensive MVO had significantly worse LVEF at 4–6 and 30 days.
    • The incidence of extensive MVO was numerically but not statistically lower in the TH group (11%) compared to controls (24%).
    • TH may reduce MVO and subsequently infarct size, and is currently being tested in the COOL AMI pivotal study.

    Abstract

    Objective

    COOL AMI EU pilot was a multi-center, randomized controlled trial to assess feasibility and safety of rapid intravascular therapeutic hypothermia (TH) in conscious patients with anterior ST-elevation myocardial infarction (STEMI) undergoing primary PCI (PPCI). We report the effect of hypothermia upon microvascular obstruction (MVO).

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