Interventions for Secondary Mitral Regurgitation in Patients With Heart Failure: A Network Meta-Analysis of Randomized Controlled Comparisons of Surgery, Medical Therapy and Transcatheter Intervention
Highlights
- • Transcatheter leaflet repair was associated with significantly reduced 24-month mortality compared with medical therapy.
- • Valvular interventions were associated with lower rates of recurrent moderate-severe MR.
- • Sub-valvular interventions displayed superior trends regarding clinical and functional outcomes.
ABSTRACT
Background
Mitral regurgitation (MR) in heart failure (HF) notoriously carries a poor prognosis. While there are multiple interventional options for treatment, the optimal intervention remains controversial. Therefore, we aimed to evaluate the efficacy and safety of surgery, medical therapy, and transcatheter intervention in secondary MR.