Low-Risk Transcatheter Versus Surgical Aortic Valve Replacement – An Updated Meta-Analysis of Randomized Controlled Trials
Highlights
- • We have performed a systematic review and meta-analysis of transcatheter aortic valve replacement (TAVR) in severe aortic stenosis patients with low surgical risk compared with surgical aortic valve replacement (SAVR).
- • This report is especially timely considering the recent interest in this area following the publication of 2 recent randomized trials on this topic (PARTNER3 and the EVOLUT trial).
- • TAVR was however associated with improved early mortality, rates of atrial fibrillation, major bleeding and rehospitalization.
- • TAVR was associated with an increase in pacemaker implantation rates and paravalvular regurgitation with transcatheter valves, mostly seen with Core valves.
- • We conclude that in appropriate patients at low surgical risk undergoing bioprosthetic valve implantation, transcatheter valves should be recommended as an alternative to surgical valves.
Abstract
Objectives
To perform a meta-analysis including all available randomized controlled trials (RCTs) to date comparing transcatheter aortic valve replacement (TAVR) to surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis (AS) and low surgical risk.