A new study presented at Cardiovascular Research Technologies (CRT) 2025 shows promise for the use of the Direct Wire Pacing (DWP) method during Renal Denervation (RDN) procedures. Safety was also confirmed with zero adverse events amongst the study involving 12 patients with uncontrolled hypertension. Safety and efficacy “This feasibility study aims at showing the safety and efficacy of the DWP method as a simple technique to optimize renal denervation interventions using the delivery guidewire and a standard external pacemaker,” said Benjamin Faurie, MD, an Interventional Cardiologist at Infirmerie Protestante de Lyon, France, during Sunday’s Late-Breaking Out of the Box Studies session. The study, led by Dr. Faurie, said there was a good blood pressure response to stimulation at least on one spot (>10mmHg) and a mean systolic blood pressure response at the best spot of 31 mmHg. Between 5 to 30% of adults with hypertension are considered treatment-resistant because their hypertension is uncontrolled. Renal Denervation has been effective and safe in such populations in many trials. However, up to 37% of patients do not experience any clinical benefits from this procedure, mostly due to inadequate patient selection and/or incomplete denervation. Electroducer Dr. Faurie, who is also the founder of the Direct Wire Pacing device Electroducer, proposed the use of renal nerve stimulation (RNS) as a method to test patient selection and RDN’s immediate effect. Recent animal and clinical studies reported that patients with a significant increase in blood pressure (BP) during RNS have more efficient BP‐lowering effect following RDN. According to these recent clinical studies, performing RNS immediately after RDN could also be useful to assess the degree of RDN effectiveness. “By avoiding RDN in non-responder patients, and by avoiding the use of an expensive pacing catheter, the DWP technique for RNS during RDN procedure should significantly reduce the cost of the procedures and improve patient outcome,” said Dr. Faurie. Research methodology The feasibility study involved 12 patients with uncontrolled hypertension who were candidates for renal denervation with the Paradise System (Recor Medical) The primary objective was to investigate the safety and efficacy of RNS performed by the DWP technique. Safety was assessed by the prevalence of adverse events related to RNS and the procedure until patient discharge. Efficacy was measured by the effects of stimulation on systolic blood pressure (SBP) at the site with the maximum SBP change. Image Credit: Bailey G. Salimes Image Caption: Benjamin Faurie, MD, presents during the Late-Breaking Out of the Box Studies session at Cardiovascular Research Technologies (CRT) 2025 on Sunday.