Among patients with heart failure with reduced ejection fraction (HFrEF) undergoing mitral valve transcatheter edge-to-edge repair (M-TEER) for treatment of secondary mitral regurgitation (SMR), increasing the dosage of guideline-directed medical therapy (GDMT) after M-TEER was associated with marked improvement in MR, survival and freedom from HF hospitalization (HFH), a new registry analysis shows.