Women undergoing transcatheter aortic valve replacement (TAVR) in the Gulf region had comparable outcomes and attributes to men in the Gulf TAVR registry, according to new WIN GULF TAVR registry data. Mirvat Alasnag, MD, from the King Fahad Armed Forces Hospital (KFAFH), Jeddah, Saudi Arabia, presented the data Tuesday at Cardiovascular Research Technologies (CRT) 2022 as a CRT First Report. Findings from the prospective international registry show that while numerically, women had higher rehospitalizations for cardiac causes and myocardial infarction (MI) at 1 year, their overall survival was better. Alasnag noted that the Women IN GULF Transcatheter Aortic Valve Replacement Registry (WIN GULF TAVR) was set up as a pre-specified sub-analysis of the wider Gulf TAVR Registry after previous registry data from the WIN-TAVI registry did not include women from the Gulf region but reported that baseline atrial fibrillation (AF) and prior percutaneous coronary intervention (PCI) were independent predictors of the 1-year death or stroke. “The objectives of this analysis are to describe the risk profile, procedural success and complications and one-year composite outcome of death and rehospitalizations as well as the individual components of the composite outcomes in women who had undergone TAVR in the Gulf region at one year,” said Alasnag. “It aims to identify differences in the risk profile and drivers of events.” Study details The study analyzed multicenter retrospective observational data collected between January 2017 and December 2019 across the Gulf region, including Saudi Arabia, Oman, Bahrain and Kuwait. Baseline characteristics, procedural details and success, in addition to 1-year outcomes, were recorded. Valve Academic Research Consortium 2 definitions were referenced for procedural complications and 1-year outcomes, with the primary outcome set as a composite of all-cause death and rehospitalizations at 1year. Secondary outcomes were individual components of the composite, said Alasnag. A total of 348 women (44% of the GULF TAVR registry) were included in the analysis. They had a mean age of 74.1 years, she noted, adding that the mean Society of Thoracic Surgery (STS) score was 5.30 (SD 4.35). Primary endpoint outcomes were found in 12.4% (95% confidence interval [CI]: 9.3% 16.2%), while death occurred in 4.3% (95% CI 2.6% to 7.0%), and 9.8% were rehospitalized (95% CI 7.1% to 13.3%) with 7.2% (95% CI 4.9% to 10.4%) related to cardiac causes. “Baseline demographics and procedural success were comparable to the male cohort of the main GULF TAVR registry, although the 1-year event rate was too low to detect drivers of events,” Alasnag noted, adding that the current registry data suggest that women in the Gulf region had comparable outcomes and attributes to men in the Gulf TAVR registry. “Numerically, women had higher rehospitalizations for cardiac causes and MI at 1 year, yet the overall survival was better. These observations warrant a larger cohort to confirm these differences and identify drivers of events.”